Downregulation of receptors의 3가지 mechanism

GnRH agonist의 작용기전 3가지
다운레귤레이션
DUL
Desensitization by autophosphorylation of the cytoplasmic segment of receptor
Uncoupling of the regulatory and catalytic subunits of adenylate cyclase enzyme
Loss of receptors by internalization (relatively slow mechanism)